Nuclear Magnetic Resonance
NMR spectroscopy is a very powerful and one of the most informative analytical techniques. Advantages of this type of instrumental analysis also include its non-destructive character that allows a full recovery of the original sample.
We provide service on NMR analysis, consultancy and training for internal and external customers.
The full range of solution NMR experiments are offered at operating frequencies of 300 MHz, including routine 1- and 2D proton and carbon-13 experiments. Advice on experiment selection and data interpretation is also available.
Together with routine NMR experiments, we offer our help in identification of unknown materials, determination of chemical structures, properties of novel products, quantification of components in a mixture and analysis of conformational and molecular dynamics.
Samples can be prepared by the operator. In this case, cost of sample preparation and solvent are borne by the customer. Deuterated solvents are charged at cost price or may be supplied by the customer.
If you are preparing samples by yourself, make sure that you use NMR tube of the following dimensions: 5 mm - diameter, 7-8’’ – length. Quality of the results will be greater in you obey the following simple rules in the preparation of your sample:
- Check that the NMR tube and cap are clean and dry.
- Do not heat tubes or store them in an oven as it is likely to distort the tube.
- Use roughly 5-10 mg for 1H, 20-50 mg for 13C experiments depending on the nature of your product. Using higher concentrations may reduce time for the data collection, but it may increase viscosity of solutions leading to poor resolution.
- Make up the sample in a small tube or test tube in the appropriate amount of solvent and transfer into the NMR tube – use ~0.7ml of solvent.
- Sample length in the NMR tube should be ~5 cm long using 0.7 ml of solvent. Shorter samples will produce spectra with much poorer resolution.
- Solid particles, especially those in cloudy solution drastically reduce spectral quality. Do not use large quantities of solvent to dissolve samples, use the minimum volume and filter (either use tissue wrapped round the end of a Pasteur pipette, or filter through a Pasteur pipette plugged with a piece of tissue).
Do NOT use NMR tubes or caps with any sign of damage. The operator will reject samples for analysis if they are submitted in damaged tubes / caps or in case of any evidence of sample leakage.
Arrange with the operator prior to preparation of sample solutions if the sample is unstable.
Charges & Booking
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Dr Anton V. Dolzhenko
Tel: +603 5514 5867
Tan Ping Wey
Tel: +603 5516 4531
Building 4, Level 6