Dr Reyhaneh Farghadani

Assistant Lecturer

Jeffrey Cheah School of Medicine & Health Sciences

Email: reyhaneh.farghadani@monash.edu
Tel: +603 5514 4996
Office: Room 4-4-70

ORCID ID: https://orcid.org/0000-0002-3481-573X

Profile Summary

Dr Reyhaneh is an Assistant Lecturer at Jeffrey Cheah School of Medicine and Health Sciences (JCSMHS). She obtained her PhD degree in Molecular Medicine from University of Malaya (UM) in 2019. Her PhD project was awarded the Postgraduate Research Grant from University of Malaya focusing on molecular and cellular mechanism of action of anti-breast cancer activity of novel Schiff-based compounds as the promising anticancer agents in breast cancer treatment.

Dr Reyhaneh is a scientist with keen interests in anti-cancer drug discovery and development. Her certain unique set of skills, knowledge, and experiences has led to several publications in internationally reputed high impact journals. She has also been awarded the JCSMHS Early Career Researcher (ECR) grant 2021. Last but not the least, Dr Reyhaneh's dream is to make a difference in fighting against breast cancer, and she is currently working on natural product in treating breast cancer.

Qualifications

  • Doctor of Philosophy (PhD: Molecular Medicine), University Malaya (UM), Malaysia
  • Master of Science (MSc: Biotechnology), University Technology Malaysia (UTM)
  • Bachelor of Science (BSc: Cellular & Molecular Biology - Genetics), Iran

Involvement in Professional Organizations

  • The European Association for Cancer Research (member)
  • American Association for Cancer Research (member)

Research / Education interests

Dr Reyhaneh’s research path started with exploring genetic polymorphism of the mitochondrial DNA cytochrome b gene among the Malay population. However, her passion to make a difference in fighting against cancer in addition to expanding her research skills and expertise sparked her interest to change the direction of her research road to cancer therapy field. Therefore, she embarked her PhD journey with focus on cancer drug discovery, and the significant outcome of her research includes the determination of molecular and cellular mechanism and the mode of action of novel synthetic Schiff-based compounds, as the biologically active and promising anticancer agents, in breast cancer treatment.

Dr Reyhaneh’s main research interest is cancer drug discovery and development. Currently, she is interested in phytochemical-based anticancer agents, particularly promising role of curcumin, a bioactive component of golden spice turmeric, and its analogues in cancer therapy. She is enthusiastic to understand their key role in regulation of dysregulated signaling pathways in cancer with particular focus on breast cancer. Her interest also expands to how this magic compound functions as chemosensitizer for tumors and as chemoprotector for normal organs in cancer chemotherapy treatment.

Dr Reyhaneh hopes that her work can deepen and expand the knowledge about the multifunctional mechanism of curcumin anticancer activity and provide a framework for future studies and insights to improve its efficiency in clinical practice. She believes that curcumin-based drugs will be eventually marketed as a cure for cancer soon.

Publications

Book Chapters

Farghadani, R. and Naidu, R., 2021. The Role of Apoptosis as a Double-Edge Sword in Cancer. In: Regulation and Dysfunction of Apoptosis. IntechOpen. DOI: 10.5772/intechopen.97844. Available from: https://www.intechopen.com/online-first/76935

Journal Articles/Conferences

Farghadani, R. and Naidu, R., 2021. Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer. Cancers, 13(14), p.3427.

Seifaddinipour, M., Farghadani, R., Namvar, F., Bin Mohamad, J. and Muhamad, N.A., 2020. In Vitro and In Vivo Anticancer Activity of the Most Cytotoxic Fraction of Pistachio Hull Extract in Breast Cancer. Molecules, 25(8), p.1776.

Abood, W.N., Bradosty, S.W., Shaikh, F.K., Salehen, N.A., Farghadani, R., Agha, N.F.S., Al-Medhtiy, M.H., Kamil, T.D.A., Agha, A.S. and Abdulla, M.A., 2020. Garcinia mangostana peel extracts exhibit hepatoprotective activity against thioacetamide-induced liver cirrhosis in rats. Journal of Functional Foods, 74, p.104200.

Narayanan, P., Farghadani, R., Nyamathulla, Sh., Rajarajeswaran, J., Thirugnanasampandan, R., Bhuwaneswari, G. Natural quinones induce ROS-mediated apoptosis and inhibit cell migration in PANC-1 human pancreatic cancer cell line (Under review in Journal of Biochemical and Molecular Toxicology).

Farghadani, R., Rajarajeswaran, J., Hashim, N.B.M., Abdulla, M.A, 2019. In vivo acute toxicity evaluation and in vitro molecular mechanism study of antiproliferative activity of a novel indole Schiff base β-diiminato manganeseІІІ complex in hormone-dependent and triple negative breast cancer cells. Peer J, 7:e7686. 2018 Seifaddinipour, M., Farghadani, R., Namvar, F., Mohamad, J. and Abdul Kadir, H., 2018. Cytotoxic Effects and AntiAngiogenesis Potential of Pistachio (Pistacia vera L.) Hulls against MCF-7 Human Breast Cancer Cells. Molecules, 23(1), p.110.5

Farghadani, R., Rajarajeswaran, J., Hashim, N.B.M., Abdulla, M.A. and Muniandy, S., 2017. A novel β-diiminato manganese III complex as the promising anticancer agent induces G 0/G 1 cell cycle arrest and triggers apoptosis via mitochondrial-dependent pathways in MCF-7 and MDA-MB- 231 human breast cancer cells. RSC Advances, 7(39), pp.24387-24398.

Devagi, G., Reyhaneh, F., Dallemer, F., Jayakumar, R., Kalaivani, P. and Prabhakaran, R., 2017. Morphological and in vitro evaluation of programmed cell death in MCF-7 cells by new organoruthenium(ii) complexes. New Journal of Chemistry, 41(16), pp.8620-8636.

Reyhaneh Farghadani, Batoul Sadat Haerian, Nader Ale Ebrahim, and Sekaran Muniandy. 35-Year Research History of Cytotoxicity and Cancer: a Quantitative and Qualitative Analysis. Asian Pac J Cancer Prev. 2016;17(7):3139-45.

Reyhaneh Frghadani, Jayakumar Rajarajeswaran, Najihah Binti Mohd Hashim, Shatrah Binti Othman. Anti-proliferative Activity of a Novel Manganese (III) Schiff Base Complex through Inducing Apoptosis in Human Breast Cancer. The 21st Biological Sciences Graduate Congress (BSGC), Kuala Lumpur, 15-17 December 2016. (Oral)

Reyhaneh, F. and Arman Amani, B., 2015. Nucleotide variation of the mitochondrial cytochrome B gene in the Malay population. Romanian Journal of Legal Medicine, 23(1), pp.57-60.

Reyhaneh Farghadani, Solmaz Khademi, Ali Mohammad Ahadi, Hoda Ayat, Mehran Arabi. The homology study of some Hox family genes between invertebrates and human. First National conference of6 biology Student. Shahrekord University. Shahrekord Iran.

Research Grants

[Grant...]

Research Supervision

Honors and Awards

2021 Early Career Researcher (ECR) Grant, Monash University Malaysia
2015–2019 Postgraduate research grant (PPP), University of Malaya
2015–2018 University of Malaya international scholarship (iGRAS)
2013 High distinction in M.Sc.
2009 Ranked in the top 15% students in B.Sc
2009 Awarded as a distinguished student by the University Committee for the Exceptional Talents, University of Shahrekord
2005 Ranked in the top 1% in the Nationwide University Entrance Exam among 400,000 participants